9ème édition du Congrès Biotech du Grand Ouest

Fil rouge: Les Biotechnologies bleues

Palais des congrès de Saint-Brieuc

31 mars 2016

Les conférences plénières / Gurvan Michel

L'introduction ; l'exposé ; img-logoPdfPetitFormat les transparents (pdf) ; les questions ; le résumé

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Introduction de la conférence de Gurvan Michel


Mohamed Jebbar, enseignant-chercheur en microbiologie
au sein du LM2E (Laboratoire de microbiologie des environnements extrêmes)
à l’Université de Bretagne Occidentale


Discovery of novel enzymes for the valorization of algal biomass: from genomes of marine bacteria to blue biotechnology [35:19 mn]

Gurvan Michel, Marine Glycobiology Group (UMR UPMC - CNRS 8227, Station Biologique de Roscoff)


Trois questions à Gurvan Michel [5:49 mn]


Seaweeds dominate the primary production of coastal environments. This large biomass is mainly constituted by polysaccharides. But marine algal polysaccharides display a huge chemical diversity and greatly differ in composition and structure from their terrestrial counterparts. Several algal polysaccharides (e.g. agars, carrageenans, alginates...) are already widely used in various industries. To develop novel, high-value products from algal biomass, there is an urgent need for specific enzymes modifying the structure and thus the biological and/or physicochemical properties of these biopolymers.

The most promising sources of such enzymes are marine heterotrophic bacteria which use seaweeds as a source of nutrients. Our group is developing Zobellia galactanivorans as a model marine bacterium for studying the bioconversion of algal polysaccharides. The sequencing of the genome of Z. galactanivorans has confirmed its huge capacity for polysaccharide utilization, with the presence of 141 glycoside hydrolases and 72 sulfatases. We have already started to exploit these genomic data. Using phylogenetic and comparative genomic approaches, we have also discovered novel families of enzymes involved in the degradation of algal polysaccharides In depth structural and biochemical analyses of these new polysaccharidases have revealed that Z. galactinovorans possesses a complex systems to deconstruct the cell wall of brown and red algae.

Altogether, these works have enlightened the richness of marine bacteria as sources of original enzymes and the necessity to combine genomic and classical biochemical approaches to discover these enzymatic tools needed for the valorization of algal biomass.

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